CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

The non-polymorphic nature of CD1 proteins creates a situation in which T cells with invariant T cell receptors (TCRs), like CD1d-specific NKT cells, are present in all humans. CD1b is an abundant protein on human dendritic cells that presents M. tuberculosis (Mtb) lipid antigens to T cells. Analysi...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Lopez, Kattya, Iwany, Sarah K., Suliman, Sara, Reijneveld, Josephine F., Ocampo, Tonatiuh A., Jimenez, Judith, Calderon, Roger, Lecca, Leonid, Murray, Megan B., Moody, D. Branch, Van Rhijn, Ildiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033476/
https://ncbi.nlm.nih.gov/pubmed/32117314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00199
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