Malnutrition Decreases Antibody Secreting Cell Numbers Induced by an Oral Attenuated Human Rotavirus Vaccine in a Human Infant Fecal Microbiota Transplanted Gnotobiotic Pig Model

Human rotavirus (HRV) is a leading cause of morbidity and mortality in children, especially in developing countries. Malnutrition is prevalent in these countries, which may contribute to the decreased oral vaccine efficacy, posing a concern for global health. Neonatal gnotobiotic (Gn) pigs closely r...

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Udgivet i:Front Immunol
Main Authors: Michael, Husheem, Langel, Stephanie N., Miyazaki, Ayako, Paim, Francine C., Chepngeno, Juliet, Alhamo, Moyasar A., Fischer, David D., Srivastava, Vishal, Kathayat, Dipak, Deblais, Loic, Rajashekara, Gireesh, Saif, Linda J., Vlasova, Anastasia N.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033455/
https://ncbi.nlm.nih.gov/pubmed/32117313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00196
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