RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters

In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including Kaposi’s sarcoma-associated herpesvirus (KSHV) and...

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Vydáno v:PLoS Pathog
Hlavní autoři: Hartenian, Ella, Gilbertson, Sarah, Federspiel, Joel D., Cristea, Ileana M., Glaunsinger, Britt A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032723/
https://ncbi.nlm.nih.gov/pubmed/32032393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008269
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