RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters

In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including Kaposi’s sarcoma-associated herpesvirus (KSHV) and...

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Publicado en:PLoS Pathog
Autores principales: Hartenian, Ella, Gilbertson, Sarah, Federspiel, Joel D., Cristea, Ileana M., Glaunsinger, Britt A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032723/
https://ncbi.nlm.nih.gov/pubmed/32032393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008269
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