RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters

In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including Kaposi’s sarcoma-associated herpesvirus (KSHV) and...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Hartenian, Ella, Gilbertson, Sarah, Federspiel, Joel D., Cristea, Ileana M., Glaunsinger, Britt A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032723/
https://ncbi.nlm.nih.gov/pubmed/32032393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008269
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