Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice

A novel oral protein delivery system with enhanced intestinal penetration and improved antigen stability based on chitosan (CS) nanoparticles and antigen-cyclodextrin (CD) inclusion complex was prepared by a precipitation/coacervation method. Ovalbumin (OVA) as a model antigen was firstly encapsulat...

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Опубликовано в: :Asian J Pharm Sci
Главные авторы: He, Muye, Zhong, Chen, Hu, Huibing, Jin, Yu, Chen, Yanzuo, Lou, Kaiyan, Gao, Feng
Формат: Artigo
Язык:Inglês
Опубликовано: Shenyang Pharmaceutical University 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032233/
https://ncbi.nlm.nih.gov/pubmed/32104451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2018.04.001
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