The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes

A novel biocompatible and biodegradable drug-delivery nanoparticle (NP) has been developed to minimize the severe side effects of the poorly water-soluble anticancer drug paclitaxel (PTX) for clinical use. PTX was loaded into the hydrophobic cavity of a hydrophilic cyclodextrin derivative, heptakis...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Ye, Ya-Jing, Wang, Yun, Lou, Kai-Yan, Chen, Yan-Zuo, Chen, Rongjun, Gao, Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498727/
https://ncbi.nlm.nih.gov/pubmed/26170666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S83508
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