Preparation and evaluation of poly(l-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells

In this study, a pH-sensitive micelle self-assembled from poly(l-histidine) based triblock copolymers of poly(ethylene glycol)–poly(d,l-lactide)–poly(l-histidine) (mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin (Dox) delivery for cancer chemotherapy. Dox was loaded into the mi...

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Dettagli Bibliografici
Pubblicato in:Asian J Pharm Sci
Autori principali: Jia, Nan, Ye, Yuqing, Wang, Qi, Zhao, Xiuli, Hu, Haiyang, Chen, Dawei, Qiao, Mingxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Shenyang Pharmaceutical University 2017
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Original Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032172/
https://ncbi.nlm.nih.gov/pubmed/32104356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2017.05.007
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