Circulating 27-hydroxycholesterol and breast cancer tissue expression of CYP27A1, CYP7B1, LXR-β, and ERβ: results from the EPIC-Heidelberg cohort

BACKGROUND: Experimental and epidemiological studies demonstrate a role for 27-hydroxycholesterol (27HC) in breast cancer development, though results are conflicting. Cholesterol 27-hydroxylase (CYP27A1) and oxysterol 7-alpha-hydroxylase (CYP7B1) regulate 27HC concentrations, while differential expr...

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Bibliographic Details
Published in:Breast Cancer Res
Main Authors: Le Cornet, Charlotte, Walter, Britta, Sookthai, Disorn, Johnson, Theron S., Kühn, Tilman, Herpel, Ester, Kaaks, Rudolf, Fortner, Renée T.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031866/
https://ncbi.nlm.nih.gov/pubmed/32075687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-1253-6
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