Sensory neuron–derived Na(V)1.7 contributes to dorsal horn neuron excitability

Expression of the voltage-gated sodium channel Na(V)1.7 in sensory neurons is required for pain sensation. We examined the role of Na(V)1.7 in the dorsal horn of the spinal cord using an epitope-tagged Na(V)1.7 knock-in mouse. Immuno–electron microscopy showed the presence of Na(V)1.7 in dendrites o...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Alles, Sascha R. A., Nascimento, Filipe, Luján, Rafael, Luiz, Ana P., Millet, Queensta, Bangash, M. Ali, Santana-Varela, Sonia, Zhou, Xuelong, Cox, James J., Okorokov, Andrei L., Beato, Marco, Zhao, Jing, Wood, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030926/
https://ncbi.nlm.nih.gov/pubmed/32128393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax4568
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