Multiple lipid binding sites determine the affinity of PH domains for phosphoinositide-containing membranes

Association of peripheral proteins with lipid bilayers regulates membrane signaling and dynamics. Pleckstrin homology (PH) domains bind to phosphatidylinositol phosphate (PIP) molecules in membranes. The effects of local PIP enrichment on the interaction of PH domains with membranes is unclear. Mole...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Yamamoto, Eiji, Domański, Jan, Naughton, Fiona B., Best, Robert B., Kalli, Antreas C., Stansfeld, Phillip J., Sansom, Mark S. P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2020
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030919/
https://ncbi.nlm.nih.gov/pubmed/32128410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay5736
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