Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22–dependent manner

Colitis, an inflammatory bowel disease, is caused by a variety of factors, but luminal microbiota are thought to play crucial roles in disease development and progression. Indole is produced by gut microbiota and is believed to protect the colon from inflammatory damage. In the current study, we inv...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Busbee, Philip B., Menzel, Lorenzo, Alrafas, Haider Rasheed, Dopkins, Nicholas, Becker, William, Miranda, Kathryn, Tang, Chaunbing, Chatterjee, Saurabh, Singh, Udai P., Nagarkatti, Mitzi, Nagarkatti, Prakash S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030851/
https://ncbi.nlm.nih.gov/pubmed/31941837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127551
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