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Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells

Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have had limited success. The focus is therefore shifting...

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Podrobná bibliografie
Vydáno v:R Soc Open Sci
Hlavní autoři: Grubelnik, Vladimir, Markovič, Rene, Lipovšek, Saška, Leitinger, Gerd, Gosak, Marko, Dolenšek, Jurij, Valladolid-Acebes, Ismael, Berggren, Per-Olof, Stožer, Andraž, Perc, Matjaž, Marhl, Marko
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029933/
https://ncbi.nlm.nih.gov/pubmed/32218947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.191171
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