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First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in ex vivo mouse heart

The hexosamine biosynthesis pathway (HBP) branches from glycolysis and forms UDP-GlcNAc, the moiety for O-linked β-GlcNAc (O-GlcNAc) post-translational modifications. An inability to directly measure HBP flux has hindered our understanding of the factors regulating protein O-GlcNAcylation. Our goals...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Olson, Aaron K., Bouchard, Bertrand, Zhu, Wei Zhong, Chatham, John C., Des Rosiers, Christine
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029105/
https://ncbi.nlm.nih.gov/pubmed/31915250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010565
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