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Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice

Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two break points in the tricarboxylic acid cycle of M1 macrophages, and aspartate‐arginosuccinate shunt compensates them. Aminoox...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Zhao, Pei, Zhou, Wenjing, Zhang, Yanxia, Li, Jingjing, Zhao, Ye, Pan, Lihua, Shen, Zhenya, Chen, Weiqian, Hui, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028849/
https://ncbi.nlm.nih.gov/pubmed/31930778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14972
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