Aminooxyacetic acid attenuates post‐infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice

Excessive activation of pro‐inflammatory M1 macrophages following acute myocardial infarction (MI) aggravates adverse cardiac remodelling and heart dysfunction. There are two break points in the tricarboxylic acid cycle of M1 macrophages, and aspartate‐arginosuccinate shunt compensates them. Aminoox...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Zhao, Pei, Zhou, Wenjing, Zhang, Yanxia, Li, Jingjing, Zhao, Ye, Pan, Lihua, Shen, Zhenya, Chen, Weiqian, Hui, Jie
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028849/
https://ncbi.nlm.nih.gov/pubmed/31930778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14972
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