Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome

BACKGROUND AND PURPOSE: Ischemic stroke significantly perturbs neuronal homeostasis leading to a cascade of pathologic events causing brain damage. In this study, we assessed acute stroke outcome after chemogenetic inhibition of forebrain excitatory neuronal activity. METHODS: We generated hM4Di-TG...

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Bibliographic Details
Published in:Exp Neurol
Main Authors: Wang, Ya-chao, Galeffi, Francesca, Wang, Wei, Li, Xuan, Lu, Liping, Sheng, Huaxin, Hoffmann, Ulrike, Turner, Dennis A., Yang, Wei
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028516/
https://ncbi.nlm.nih.gov/pubmed/31962128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2020.113206
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