Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model

OBJECTIVE: Our study was designed to investigate whether the indoleamine-2,3-dioxygenase (IDO)-mediated kynurenine/tryptophan (KYN/TRP) pathway participates in the development of emotional deficits from ethanol addiction/withdrawal mice. METHODS: The expression of proinflammatory factors, including...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Jiang, Xi, Lin, Qian, Xu, Lexing, Chen, Ziwei, Yan, Qizhi, Chen, Lei, Yu, Xuefeng
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026684/
https://ncbi.nlm.nih.gov/pubmed/32116558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2020.00011
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