Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice

Neat1 is a long noncoding RNA (lncRNA) that serves as an architectural component of the nuclear bodies known as paraspeckles. Two isoforms of Neat1, the short isoform Neat1_1 and the long isoform Neat1_2, are generated from the same gene locus by alternative 3′ processing. Neat1_1 is the most abunda...

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Publicado en:RNA
Main Authors: Isobe, Momo, Toya, Hikaru, Mito, Mari, Chiba, Tomoki, Asahara, Hiroshi, Hirose, Tetsuro, Nakagawa, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025509/
https://ncbi.nlm.nih.gov/pubmed/31822595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072587.119
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