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Systematic genetics and single‐cell imaging reveal widespread morphological pleiotropy and cell‐to‐cell variability

Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to‐cell phenotypic variability, we combined automated yeast genetics, high‐content screening and neural network‐based...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Mattiazzi Usaj, Mojca, Sahin, Nil, Friesen, Helena, Pons, Carles, Usaj, Matej, Masinas, Myra Paz D, Shuteriqi, Ermira, Shkurin, Aleksei, Aloy, Patrick, Morris, Quaid, Boone, Charles, Andrews, Brenda J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025093/
https://ncbi.nlm.nih.gov/pubmed/32064787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20199243
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