HPV16 E5 Mediates Resistance to PD-L1 Blockade and can be targeted with Rimantadine in Head and Neck Cancer

There is a critical need to understand mechanisms of resistance and develop combinatorial strategies to improve responses to checkpoint blockade immunotherapy (CBI). Here we uncover a novel mechanism by which the human papillomavirus (HPV) inhibits the activity of CBI in head and neck squamous cell...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Miyauchi, Sayuri, Sanders, P. Dominick, Guram, Kripa, Kim, Sangwoo S., Paolini, Francesca, Venuti, Aldo, Cohen, Ezra E. W., Gutkind, J. Silvio, Califano, Joseph A., Sharabi, Andrew B.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024675/
https://ncbi.nlm.nih.gov/pubmed/31848196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1771
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