PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice

Metformin is the first-line drug for type 2 diabetes mellitus control. It is established that this drug traffics through OCT-2 and MATE-1 transporters in kidney tubular cells and is excreted in its unaltered form in the urine. Hereby, we provide evidence that points towards the metformin-dependent u...

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Vydáno v:Molecules
Hlavní autoři: Arruda, Adriano Cleis, Perilhão, Mauro Sérgio, Santos, Warley Almeida, Gregnani, Marcos Fernandes, Budu, Alexandre, Neto, José Cesar Rosa, Estrela, Gabriel Rufino, Araujo, Ronaldo Carvalho
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024194/
https://ncbi.nlm.nih.gov/pubmed/31963528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25020392
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