Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5

The voltage-gated potassium channel Kv1.5, which mediates the cardiac ultra-rapid delayed-rectifier (I(Kur)) current in human cells, has a crucial role in atrial fibrillation. Therefore, the design of selective Kv1.5 modulators is essential for the treatment of pathophysiological conditions involvin...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Zhao, Zefeng, Ruan, Songsong, Ma, Xiaoming, Feng, Qian, Xie, Zhuosong, Nie, Zhuang, Fan, Peinan, Qian, Mingcheng, He, Xirui, Wu, Shaoping, Zhang, Yongmin, Zheng, Xiaohui
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022446/
https://ncbi.nlm.nih.gov/pubmed/31861703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010010
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