Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in amyloid deposits of different origins, and its interaction with...

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Vydáno v:Biomolecules
Hlavní autoři: Gharibyan, Anna L., Islam, Tohidul, Pettersson, Nina, Golchin, Solmaz A., Lundgren, Johanna, Johansson, Gabriella, Genot, Mélany, Schultz, Nina, Wennström, Malin, Olofsson, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022431/
https://ncbi.nlm.nih.gov/pubmed/31947546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010134
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