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RNA Polymerase II Promoter-Proximal Pausing and Release to Elongation Are Key Steps Regulating Herpes Simplex Virus 1 Transcription

Herpes simplex virus 1 (HSV-1) genes are transcribed by cellular RNA polymerase II (Pol II). Expression of viral immediate early (α) genes is followed sequentially by early (β), late (γ(1)), and true late (γ(2)) genes. We used precision nuclear run-on with deep sequencing to map and to quantify Pol...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Birkenheuer, Claire H., Baines, Joel D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022368/
https://ncbi.nlm.nih.gov/pubmed/31826988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02035-19
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