Both IgM and IgG Antibodies against Polyethylene Glycol Can Alter the Biological Activity of Methoxy Polyethylene Glycol-Epoetin Beta in Mice

Pre-existing antibodies that bind polyethylene glycol are present in about 40% of healthy individuals. It is currently unknown if pre-existing anti-polyethylene glycol (PEG) antibodies can alter the bioactivity of pegylated drugs with a single long PEG chain, which represents the majority of newly d...

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Gepubliceerd in:Pharmaceutics
Hoofdauteurs: Chang, Tien-Ching, Chen, Bing-Mae, Lin, Wen-Wei, Yu, Pei-Hua, Chiu, Yi-Wen, Chen, Yuan-Tsong, Wu, Jer-Yuarn, Cheng, Tian-Lu, Hwang, Daw-Yang, Roffler, Steve
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022322/
https://ncbi.nlm.nih.gov/pubmed/31877813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12010015
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