Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no cell surface expression in nonolfactory cells due to endoplasmic reticulum retention, which has slowed down biochemical s...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Ikegami, Kentaro, de March, Claire A., Nagai, Maira H., Ghosh, Soumadwip, Do, Matthew, Sharma, Ruchira, Bruguera, Elise S., Lu, Yueyang Eric, Fukutani, Yosuke, Vaidehi, Nagarajan, Yohda, Masafumi, Matsunami, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022149/
https://ncbi.nlm.nih.gov/pubmed/31974307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915520117
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