Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no cell surface expression in nonolfactory cells due to endoplasmic reticulum retention, which has slowed down biochemical s...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Ikegami, Kentaro, de March, Claire A., Nagai, Maira H., Ghosh, Soumadwip, Do, Matthew, Sharma, Ruchira, Bruguera, Elise S., Lu, Yueyang Eric, Fukutani, Yosuke, Vaidehi, Nagarajan, Yohda, Masafumi, Matsunami, Hiroaki
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022149/
https://ncbi.nlm.nih.gov/pubmed/31974307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915520117
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