Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no cell surface expression in nonolfactory cells due to endoplasmic reticulum retention, which has slowed down biochemical s...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ikegami, Kentaro, de March, Claire A., Nagai, Maira H., Ghosh, Soumadwip, Do, Matthew, Sharma, Ruchira, Bruguera, Elise S., Lu, Yueyang Eric, Fukutani, Yosuke, Vaidehi, Nagarajan, Yohda, Masafumi, Matsunami, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022149/
https://ncbi.nlm.nih.gov/pubmed/31974307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915520117
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