Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors

Mammalian odorant receptors are a diverse and rapidly evolving set of G protein-coupled receptors expressed in olfactory cilia membranes. Most odorant receptors show little to no cell surface expression in nonolfactory cells due to endoplasmic reticulum retention, which has slowed down biochemical s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ikegami, Kentaro, de March, Claire A., Nagai, Maira H., Ghosh, Soumadwip, Do, Matthew, Sharma, Ruchira, Bruguera, Elise S., Lu, Yueyang Eric, Fukutani, Yosuke, Vaidehi, Nagarajan, Yohda, Masafumi, Matsunami, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022149/
https://ncbi.nlm.nih.gov/pubmed/31974307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915520117
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