Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain

The catalytic activity of the protease MALT1 is required for adaptive immune responses and regulatory T (Treg)-cell development, while dysregulated MALT1 activity can lead to lymphoma. MALT1 activation requires its monoubiquitination on lysine 644 (K644) within the Ig3 domain, localized adjacent to...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Schairer, Rebekka, Hall, Gareth, Zhang, Ming, Cowan, Richard, Baravalle, Roberta, Muskett, Frederick W., Coombs, Peter J., Mpamhanga, Chido, Hale, Lisa R., Saxty, Barbara, Iwaszkiewicz, Justyna, Décaillet, Chantal, Perroud, Mai, Carr, Mark D., Thome, Margot
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022147/
https://ncbi.nlm.nih.gov/pubmed/31980531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912681117
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