PARP Inhibitors in Prostate and Urothelial Cancers

Poly(ADP-ribose) polymerase (PARP) inhibitors targeting DNA repair gene mutations have shown significant clinical benefit in patients with ovarian and breast cancers. In metastatic prostate cancers, the prevalence of DNA repair gene mutations is up to 20%, and early phase studies have shown clinical...

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Udgivet i:Front Oncol
Main Authors: Garje, Rohan, Vaddepally, Raju Kumar, Zakharia, Yousef
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020773/
https://ncbi.nlm.nih.gov/pubmed/32117762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00114
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