Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label, phase II clinical trial (SAEFRIF)

BACKGROUND: Tuberculosis (TB) is a significant public health problem that causes substantial morbidity and mortality. Current first-line anti-TB chemotherapy, although very effective, has limitations including long-treatment duration with a possibility of non-adherence, drug interactions, and toxici...

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Bibliographische Detailangaben
Veröffentlicht in:Trials
Hauptverfasser: Nabisere, Ruth, Musaazi, Joseph, Denti, Paolo, Aber, Florence, Lamorde, Mohammed, Dooley, Kelly E., Aarnoutse, Rob, Sloan, Derek J., Sekaggya-Wiltshire, Christine
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020342/
https://ncbi.nlm.nih.gov/pubmed/32054536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-4132-7
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