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Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells

[Image: see text] Cancer cell–matrix interactions have been shown to enhance cancer cell survival via the activation of pro-survival signaling pathways. These pathways are initiated at the site of interaction, i.e., integrins, and thus, their inhibition has been the target of therapeutic strategies....

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Publicat a:Nano Lett
Autors principals: Young, Jennifer L., Hua, Ximeng, Somsel, Heidi, Reichart, Florian, Kessler, Horst, Spatz, Joachim P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020138/
https://ncbi.nlm.nih.gov/pubmed/31908168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.nanolett.9b04607
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