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Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics

The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential step...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Viruses
Prif Awduron: Durham, Natasha D., Howard, Angela R., Govindan, Ramesh, Senjobe, Fernando, Fels, J. Maximilian, Diehl, William E., Luban, Jeremy, Chandran, Kartik, Munro, James B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019799/
https://ncbi.nlm.nih.gov/pubmed/31952255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12010103
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