Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations

Efavirenz-based combination antiretroviral-therapy (cART) is the recommended regimen during tuberculosis (TB) therapy. In a multi-national parallel prospective-cohort study, we investigated the impact of population and pharmacogenetic variations for efavirenz pharmacokinetics, auto-induction, and im...

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Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Mugusi, Sabina, Habtewold, Abiy, Ngaimisi, Eliford, Amogne, Wondwossen, Yimer, Getnet, Minzi, Omary, Makonnen, Eyasu, Sudfeld, Christopher, Burhenne, Jürgen, Aklillu, Eleni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019112/
https://ncbi.nlm.nih.gov/pubmed/32116703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00026
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