Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations

OBJECTIVES: We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics, auto-induction and immunological outcomes in two African populations. METHODS: ART naïve HIV patients from Ethiopia (n = 285) and Tanzania (n = 209) were prospectively enrol...

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Hauptverfasser: Ngaimisi, Eliford, Habtewold, Abiy, Minzi, Omary, Makonnen, Eyasu, Mugusi, Sabina, Amogne, Wondwossen, Yimer, Getnet, Riedel, Klaus-Dieter, Janabi, Mohammed, Aderaye, Getachew, Mugusi, Ferdinand, Bertilsson, Leif, Aklillu, Eleni, Burhenne, Juergen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702506/
https://ncbi.nlm.nih.gov/pubmed/23861838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067946
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