Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis

Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium (HE); misexpression of Gata2 leads to haematopoietic disorders. Here we deleted a conserved enhancer (i4 enhancer) driving pan-endothelial expression of the zebrafish...

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發表在:Commun Biol
Main Authors: Dobrzycki, Tomasz, Mahony, Christopher B., Krecsmarik, Monika, Koyunlar, Cansu, Rispoli, Rossella, Peulen-Zink, Joke, Gussinklo, Kirsten, Fedlaoui, Bakhta, de Pater, Emma, Patient, Roger, Monteiro, Rui
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018942/
https://ncbi.nlm.nih.gov/pubmed/32054973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0798-3
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