The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats

BACKGROUND: The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim was to explore a cost-effective application of camelid anti-PCSK9 single domain...

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Detalles Bibliográficos
Publicado en:Clin Transl Med
Autores principales: Li, Xinyang, Wang, Meiniang, Zhang, Xinhua, Liu, Chuxin, Xiang, Haitao, Huang, Mi, Ma, Yingying, Gao, Xiaoyan, Jiang, Lin, Liu, Xiaopan, Li, Bo, Hou, Yong, Zhang, Xiuqing, Yang, Shuang, Yang, Naibo
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018876/
https://ncbi.nlm.nih.gov/pubmed/32056048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40169-020-0265-2
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