TAK1 signaling regulates p53 through a mechanism involving ribosomal stress

Triple-negative breast cancer (TNBC) is among the most aggressive forms of breast cancer with limited therapeutic options. TAK1 is implicated in aggressive behavior of TNBC, while means are not fully understood. Here, we report that pharmacological blockade of TAK1 signaling hampered ribosome biogen...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Zonneville, Justin, Wong, Vincent, Limoge, Michelle, Nikiforov, Mikhail, Bakin, Andrei V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018718/
https://ncbi.nlm.nih.gov/pubmed/32054925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59340-5
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