DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals

The DEPTOR-mTORC1/2 axis has been shown to play an important, but a context dependent role in the regulation of proliferation and the survival of various cancer cells in cell culture settings. The in vivo role of DEPTOR in tumorigenesis remains elusive. Here we showed that the levels of both DEPTOR...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Chen, Xiaoyu, Xiong, Xiufang, Cui, Danrui, Yang, Fei, Wei, Dongping, Li, Haomin, Shu, Jianfeng, Bi, Yanli, Dai, Xiaoqing, Gong, Longyuan, Sun, Yi, Zhao, Yongchao
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018663/
https://ncbi.nlm.nih.gov/pubmed/31685947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1085-y
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