DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals

The DEPTOR-mTORC1/2 axis has been shown to play an important, but a context dependent role in the regulation of proliferation and the survival of various cancer cells in cell culture settings. The in vivo role of DEPTOR in tumorigenesis remains elusive. Here we showed that the levels of both DEPTOR...

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Publicado en:Oncogene
Main Authors: Chen, Xiaoyu, Xiong, Xiufang, Cui, Danrui, Yang, Fei, Wei, Dongping, Li, Haomin, Shu, Jianfeng, Bi, Yanli, Dai, Xiaoqing, Gong, Longyuan, Sun, Yi, Zhao, Yongchao
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018663/
https://ncbi.nlm.nih.gov/pubmed/31685947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1085-y
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