Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri

Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites, such as gliotoxin. Gliotoxin is known to inhibit the host immune response, and genetic mutants that inactivate gli...

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Bibliographic Details
Published in:mBio
Main Authors: Knowles, Sonja L., Mead, Matthew E., Silva, Lilian Pereira, Raja, Huzefa A., Steenwyk, Jacob L., Goldman, Gustavo H., Oberlies, Nicholas H., Rokas, Antonis
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Observation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018655/
https://ncbi.nlm.nih.gov/pubmed/32047138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03361-19
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