Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake

Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging to develop antipersister strategies. Here, we report that 10-s freezing with liquid nitrogen dramatically enhances the bactericidal actio...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Zhao, Yanna, Lv, Boyan, Sun, Fengqi, Liu, Jiafeng, Wang, Yan, Gao, Yuanyuan, Qi, Feng, Chang, Zengyi, Fu, Xinmiao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018644/
https://ncbi.nlm.nih.gov/pubmed/32047133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03239-19
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