Rapid Freezing Enables Aminoglycosides To Eradicate Bacterial Persisters via Enhancing Mechanosensitive Channel MscL-Mediated Antibiotic Uptake

Bacterial persisters exhibit noninherited antibiotic tolerance and are linked to the recalcitrance of bacterial infections. It is very urgent but also challenging to develop antipersister strategies. Here, we report that 10-s freezing with liquid nitrogen dramatically enhances the bactericidal actio...

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Bibliografski detalji
Izdano u:mBio
Glavni autori: Zhao, Yanna, Lv, Boyan, Sun, Fengqi, Liu, Jiafeng, Wang, Yan, Gao, Yuanyuan, Qi, Feng, Chang, Zengyi, Fu, Xinmiao
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018644/
https://ncbi.nlm.nih.gov/pubmed/32047133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03239-19
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