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Alcohol-Mediated Calcium Signals Dysregulate Pro-Survival Snai2/PUMA/Bcl2 Networks to Promote p53-Mediated Apoptosis in Avian Neural Crest Progenitors

BACKGROUND: Prenatal alcohol exposure (PAE) causes distinctive craniofacial anomalies that arise, in part, from the apoptotic elimination of neural crest (NC) progenitors that form the face. This vulnerability of NC to alcohol is puzzling as they normally express the transcriptional repressor Snail1...

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Foilsithe in:Birth Defects Res
Main Authors: Flentke, George R., Baulch, Joshua, Berres, Mark E., Garic, Ana, Smith, Susan M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017393/
https://ncbi.nlm.nih.gov/pubmed/31021056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdr2.1508
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