Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay

Carcinogenic aromatic amines such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to form electrophilic intermediates that mutate DNA leading to carcinogenesis. Bioactivation of these carcinogens includes N-hydroxylation catalyzed by CYP1A2 followed by O-acetylation ca...

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Dettagli Bibliografici
Pubblicato in:Environ Mol Mutagen
Autori principali: Baldauf, Kristin J., Salazar-González, Raúl A., Doll, Mark A., Pierce, William M., States, J. Christopher, Hein, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017392/
https://ncbi.nlm.nih.gov/pubmed/31490564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22331
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