Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay

Carcinogenic aromatic amines such as 4-aminobiphenyl (ABP) and 2-aminofluorene (AF) require metabolic activation to form electrophilic intermediates that mutate DNA leading to carcinogenesis. Bioactivation of these carcinogens includes N-hydroxylation catalyzed by CYP1A2 followed by O-acetylation ca...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Environ Mol Mutagen
Main Authors: Baldauf, Kristin J., Salazar-González, Raúl A., Doll, Mark A., Pierce, William M., States, J. Christopher, Hein, David W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017392/
https://ncbi.nlm.nih.gov/pubmed/31490564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22331
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla