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Connecting Cancer Pathways to Tumor Engines: A Stratification Tool for Colorectal Cancer Combining Human In Vitro Tissue Models with Boolean In Silico Models

To improve and focus preclinical testing, we combine tumor models based on a decellularized tissue matrix with bioinformatics to stratify tumors according to stage-specific mutations that are linked to central cancer pathways. We generated tissue models with BRAF-mutant colorectal cancer (CRC) cells...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cancers (Basel)
Main Authors: Baur, Florentin, Nietzer, Sarah L., Kunz, Meik, Saal, Fabian, Jeromin, Julian, Matschos, Stephanie, Linnebacher, Michael, Walles, Heike, Dandekar, Thomas, Dandekar, Gudrun
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017315/
https://ncbi.nlm.nih.gov/pubmed/31861874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12010028
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