Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify...

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Veröffentlicht in:Cells
Hauptverfasser: Mazza, Giuseppe, Telese, Andrea, Al-Akkad, Walid, Frenguelli, Luca, Levi, Ana, Marrali, Martina, Longato, Lisa, Thanapirom, Kessarin, Vilia, Maria Giovanna, Lombardi, Benedetta, Crowley, Claire, Crawford, Mark, Karsdal, Morten A., Leeming, Diana J., Marrone, Giusi, Bottcher, Katrin, Robinson, Benjamin, Del Rio Hernandez, Armando, Tamburrino, Domenico, Spoletini, Gabriele, Malago, Massimo, Hall, Andrew R., Godovac-Zimmermann, Jasminka, Luong, Tu Vinh, De Coppi, Paolo, Pinzani, Massimo, Rombouts, Krista
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017194/
https://ncbi.nlm.nih.gov/pubmed/31905709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9010083
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