Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits

Eukaryotic initiation factor 6 (eIF6) is necessary for the nucleolar biogenesis of 60S ribosomes. However, most of eIF6 resides in the cytoplasm, where it acts as an initiation factor. eIF6 is necessary for maximal protein synthesis downstream of growth factor stimulation. eIF6 is an antiassociation...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Pesce, Elisa, Miluzio, Annarita, Turcano, Lorenzo, Minici, Claudia, Cirino, Delia, Calamita, Piera, Manfrini, Nicola, Oliveto, Stefania, Ricciardi, Sara, Grifantini, Renata, Degano, Massimo, Bresciani, Alberto, Biffo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017188/
https://ncbi.nlm.nih.gov/pubmed/31936702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9010172
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