Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML

The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diagnostic bone marrow (BM) from nine NPM1...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Diaz de la Guardia, Rafael, González-Silva, Laura, López-Millán, Belén, Rodríguez-Sevilla, Juan José, Baroni, Matteo L., Bueno, Clara, Anguita, Eduardo, Vives, Susana, Palomo, Laura, Lapillonne, Helene, Varela, Ignacio, Menendez, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017102/
https://ncbi.nlm.nih.gov/pubmed/31936647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11010073
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