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The importance of definitions in the study of polyQ regions: A tale of thresholds, impurities and sequence context

Polyglutamine (polyQ) regions are one of the most prevalent homorepeats in eukaryotes. It is however difficult to evaluate their prevalence because various studies claim different results. The reason is the lack of a consensus to define what is indeed a polyQ region. We have tackled this issue by st...

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Pubblicato in:Comput Struct Biotechnol J
Autori principali: Mier, Pablo, Elena-Real, Carlos, Urbanek, Annika, Bernadó, Pau, Andrade-Navarro, Miguel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Research Network of Computational and Structural Biotechnology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016039/
https://ncbi.nlm.nih.gov/pubmed/32071707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.01.012
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