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Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A
Adenosine and uridine 5′-tetra- and 5′-pentaphosphates were synthesized from an activated tetrametaphosphate ([PPN](2)[P(4)O(11)], [PPN](2)[1], PPN = bis(triphenylphosphine)iminium) and subsequently tested for inhibition of the enzymatic activity of ribonuclease A (RNase A). Reagent [PPN](2)[1] reac...
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| Опубликовано в: : | J Am Chem Soc |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7015663/ https://ncbi.nlm.nih.gov/pubmed/31651164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09760 |
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