Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A

Adenosine and uridine 5′-tetra- and 5′-pentaphosphates were synthesized from an activated tetrametaphosphate ([PPN](2)[P(4)O(11)], [PPN](2)[1], PPN = bis(triphenylphosphine)iminium) and subsequently tested for inhibition of the enzymatic activity of ribonuclease A (RNase A). Reagent [PPN](2)[1] reac...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Shepard, Scott M., Windsor, Ian W., Raines, Ronald T., Cummins, Christopher C.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015663/
https://ncbi.nlm.nih.gov/pubmed/31651164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b09760
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