Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison

CONTEXT: There is an unmet need for biomarkers of pancreatic beta-cell death to improve early diagnosis of type 1 diabetes, enroll subjects into clinical trials, and assess treatment response. To address this need, several groups developed assays measuring insulin deoxyribonucleic acid (DNA) with un...

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Veröffentlicht in:J Clin Endocrinol Metab
Hauptverfasser: Speake, Cate, Ylescupidez, Alyssa, Neiman, Daniel, Shemer, Ruth, Glaser, Benjamin, Tersey, Sarah A, Usmani-Brown, Sahar, Clark, Pamela, Wilhelm, Joshua J, Bellin, Melena D, Herold, Kevan C, Mirmira, Raghavendra G, Dor, Yuval, Evans-Molina, Carmella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Clinical Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015459/
https://ncbi.nlm.nih.gov/pubmed/31913467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgaa008
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